Sinusitis and otitis are related medical conditions because the paranasal sinuses and ears are located close to each other in the skull. Ear or facial pain is a typical symptom of sinus infection. If the sinusitis patient bends forward, ear pain or sinus pressure may increase. Sinusitis is a disease of the sinuses, whereas otitis means an infection or inflammation of the ear. The ear is divided into three parts: outer, middle and inner. The corresponding infections are medically referred to as otitis externa, otitis media and otitis interna.

Acute otitis media (AOM) is analogous to acute sinusitis in that it is a result of obstruction at the ostium of the Eustachian tube.

Administration of the Cyclamen extract-based preparation is effective in the treatment of secretory otitis media; it shortens the treatment time and avoids the use of aggressive therapies, such as myringotomies, in these patients

The Cyclamen europaeum effect on the mucous membrane of the nasal cavity, the nasopharynx and the paranasal sinuses causes an intense reflex secretion. This secretion causes intense drainage of the nasal cavity and the paranasal sinuses, resulting in increased activity of the ciliated epithelium in the Eustachian tube and exudate evacuation from the tympanic cavity of the middle ear.

The study “Use of Sinuforte® in the management of acute rhinosinusitis and secretory otitis in children” (Berezniuk VV, Chernokur AA; Journal Otorhinolaryngological Disease. 2006; (2): 65-68), concludes that the use of the preparation Sinuforte® in the combined symptomatic treatment of acute rhinosinusitis, accompanied by secretory otitis, results in rapid relief of the inflammatory process in the nasal cavity, the paranasal sinuses and the middle ear. It led to the achievement of stable positive results in the symptomatic treatment of this pathology for 96.7% of the study group patients.

Sinuforte®/Nasodren® in combination with antibiotics considerably reduces the amount of recurrences and their frequency.

The clinical effectiveness of Sinuforte®/Nasodren® in monotherapy of chronic rhinosinusitis is comparable to the effect of the therapy with antibiotics.

The received data supports a reduction in the frequency of prescribing antibiotics when patients have recurring exacerbation of rhinosinusitis, favouring the prescription of Sinuforte®/Nasodren® in monotherapy and thus reducing polypharmacy.