Monotherapy means treating a disorder with a single drug. Does monotherapy heal swollen sinuses and any other signs and symptoms of sinusitis? There is no definite answer to this question, as different research studies have arrived at different conclusions. The results of a few such studies are summarized in the article.

Systemic corticosteroid monotherapy for clinically diagnosed acute rhino sinusitis: a randomized controlled trial by Roderick P. Venekamp, et al concluded that the monotherapy did not show any clinically relevant improvement in the patients. During December 2008-April 2011, the placebo-controlled, double-blind, block-randomized trial was conducted in the Netherlands. Read the report.

The efficacy of sinuforte in the starting monotherapy of the patients presenting with acute rhino sinusitis, a randomized open study, by Semenov VF and Banashek-Meshcheriakova TV showed that the 73% patients felt better after monotherapy. The study was conducted on the patients suffering from a moderate level of acute suppurative rhino sinusitis. Get more information.

In the article Efficacy and safety of mometasone furoate nasal spray in the treatment of sinusitis or acute rhino sinusitis, Klossek JM highlighted results of a placebo-controlled, double-blind randomized study on adult patients with uncomplicated acute sinusitis. The study compared mometasone furoate as nasal spray (MFNS) monotherapy and an antibiotic therapy. The study showed that the patients given MFNS monotherapy experienced more improvement in the symptoms than the patients who received an antibiotic therapy. Klossek concluded that MFNS has an important role to play in acute sinusitis treatment. MFNS may be used as monotherapy or with antibiotics. Get more information.

Some studies revealed that Nasodren®, nasal spray by Hartington Pharmaceutical, S.L.U. can be used as monotherapy or in combination with other therapies to treat acute rhino-sinusitis. Read complete results.

The randomized study New perspective in non-invasive treatment to sinusitis was conducted in various centers by Kirukov, et al. The study tested safety and efficacy of sinuforte monotherapy in sinusitis patients. The study showed that the monotherapy is safe and effective for treating exudative sinusitis of moderate to mild severity. Read the study.

The role of Stenotrophomonas maltophilia in refractory chronic rhino sinusitis by Grindler, et al stated that the monotherapy with fluoroquinolones or TMX is effective in the patients of refractory chronic rhino sinusitis (CRS). Stenotrophomonas maltophilia, a gram-negative bacillus that is drug-resistant, may cause refractory CRS. Read the complete report.

A monotherapy or a combination of therapies is a physician’s decision. However, treating swollen sinuses is necessary because it can affect drainage and cause congestion, leading to discomfort.